We are focused on the mechanism to shut off the process in all auto inflammatory diseases.
MEFV gene (FMF) codes for the protein pyrin. Pyrin mutations were found in the MS patients. Pyrin is implicated in the maturation and secretion of the proinflammatory cytokine IL-1β. (IL-1β is a major mediator of fever and systemic inflammation).
(see table with frequency of common MEFV mutations among MS patients)
Familial Mediterranean fever-associated mutation pyrin E148Q as a potential risk factor for multiple sclerosis http://msj.sagepub.com/content/early/2012/02/14/1352458512437813.abstract
Association of Missense Mutations of Mediterranean Fever (MEFV) Gene with Multiple Sclerosis http://rd.springer.com/article/10.1007/s12031-012-9947-6/fulltext.html
The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever. http://europepmc.org/abstract/MED/22406096/reload=0;jsessionid=e0BFqCu65lnwYHdoFFjD.14
Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world’s largest FMF cohorts http://scienceindex.com/stories/1467558/Familial_Mediterranean_fever_FMF_and_multiple_sclerosis_an_association_study_in_one_of_the_worlds_largest_FMF_cohorts.html
Multiple sclerosis: the rational basis for treatment with colchicine and evening primrose oil http://www.ncbi.nlm.nih.gov/pubmed/313499?dopt=Abstract
Dysregulation of the BBB (blood brain barrier) and transendo thelial migration of activated leukocytes are among the earliest cerebro vascular abnormalities seen in multiple sclerosis (MS) brains and parallel the release of inflammatory cytokines/chemokines.
What is Multiple Sclerosis (MS) English
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